Consider this medication by mouth with or without meals as directed by your medical professional, commonly every single 4 to 6 hours as necessary. This medication might be taken with meals if abdomen upset occurs. Drink a lot of fluids when you use this medication Unless of course normally directed by your physician.
Postmarketing situations of respiratory despair, like fatalities are claimed with utilization of promethazine in pediatric people.
4)]. Observational reports have shown that concomitant usage of opioid analgesics and benzodiazepines increases the threat of drug-similar mortality in comparison with usage of opioids by yourself. Because of similar pharmacologic Houses, it truly is sensible to count on related risk with concomitant usage of opioid cough medicines and benzodiazepines, other CNS depressants, or Liquor.
Promethazine with Codeine Oral Answer may induce critical hypotension which include orthostatic hypotension and syncope in ambulatory sufferers. There may be enhanced risk in clients whose means to maintain hypertension has presently been compromised by a decreased blood quantity or concurrent administration of certain CNS depressant prescription drugs (eg.
four) ]. Observational scientific studies have shown that concomitant usage of opioid analgesics and benzodiazepines raises the chance of drug-similar mortality in comparison to usage of opioids by itself. Due to identical pharmacologic Houses, it can be reasonable to hope comparable threat with concomitant usage of opioid cough prescription drugs and benzodiazepines, other CNS depressants, or Liquor.
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Uncontrolled spasms within your experience and neck muscles, or muscles of Your whole body, arms, and legs (dystonia). These muscle spasms may cause irregular actions and body positions, and speech troubles. These spasms may take place right after 1 dose of PROMETHAZINE WITH CODEINE ORAL SOLUTION. Inform your Health care company if you have any of these indications. Enhanced chance of seizures in people with seizure Diseases. Should you have a seizure condition, PROMETHAZINE WITH CODEINE ORAL Alternative could boost how often you have seizures. Lower hypertension. A unexpected fall in blood pressure can transpire in lots of people during therapy with PROMETHAZINE WITH CODEINE ORAL SOLUTION and this may well result in you to definitely really feel dizzy, faint, lightheaded, or weak, particularly when you get up (orthostatic hypotension).
Because these reactions could be claimed voluntarily from a populace of unsure dimension, It isn't often possible to reliably estimate their frequency or create a causal partnership to drug publicity.
It's not a complete listing of probable Uncomfortable side effects. Should you observe other Unwanted effects not detailed over, Speak to your medical professional or pharmacist.
” Greater pressure in your head (improved intracranial strain). Avoid the use of PROMETHAZINE WITH CODEINE ORAL Remedy if you have a head harm or have been advised that you've got variations inside the tissue of the brain (brain lesions) or amplified pressure with your head. Neuroleptic malignant syndrome (NMS) which can cause Loss of life. Let you know healthcare provider without delay if you have any of the following signs and symptoms of NMS: superior fever
This medication can dry up and thicken mucus in your lungs, rendering it tougher to breathe and distinct your lungs. To assist avert this impact, drink a lot of fluids Until otherwise get more info directed by your health practitioner.
Promethazine is commonly distributed in entire body tissues. Promethazine has high protein binding with about 80 to ninety three% of promethazine sure to plasma proteins. Promethazine passes the blood brain barrier and also the placental barrier.
Making use of this drugs with other medication that sluggish your respiratory can cause unsafe Negative effects or Demise. Talk to your medical doctor in advance of using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiousness or seizures.
Suggest sufferers never to increase the dose or dosing frequency of Promethazine with Codeine Oral Solution due to the fact critical adverse occasions for example respiratory melancholy may perhaps happen with overdosage.